The best Side of ceesdekker
The best Side of ceesdekker
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Working with solitary-molecule optical and AFM imaging and force-spectroscopy procedures, we search for to unravel the mechanistic areas of the construction and dynamics of chromosomes. Our research pursuits incorporate:
Human Rad51 filaments on double- and solitary-stranded DNA: correlating frequent and irregular kinds with recombination functionality.
Multicolor imaging of your bacterial nucleoid and mobile division proteins with blue, orange, and around-infrared fluorescent proteins
Non-equilibrium folding of specific DNA molecules recaptured as many as one thousand moments in the good point out nanopore
That could be a desire of mine and we set to operate which has a tasty dose of naivety. This is often something that will most likely generate magnificent ends in the longer phrase, but that doesn't make any difference. You should not only want to work to the questions of tomorrow, but in addition to the inquiries of your day right after tomorrow.’
Microbiology has only been around for a century, given that we began to analyze micro-organisms more critically. I thought nanobiology was an proper phrase, due to the fact all molecular biological appropriate interactions happen with the nanoscale: a protein is some nanometres in dimensions, DNA is two nm thick.’
All parameters ended up a similar for every panel in this video clip, apart from the First placement from the 6hb rod (proven in blue) about the nanopore. Simulations that terminated early resulting from translocation of your rod through the pore are marked by a grey background.
Researching DNA loop extrusion by SMC proteins for chromosome architecture with single-molecule assays.
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1). The existing–voltage curves showed major modulations with gate voltage, even at space temperature, which was according to band bending in the ~0.six eV bandgap semiconducting nanotube. These info also confirmed that the conductance may very well be modulated by six orders of magnitude by transforming the gate voltage. The outcomes of the work — a place-temperature transistor constructed from a single carbon nanotube molecule — have been published in Character in May well 1998.
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A lot of new phenomena had been discovered, and he and his exploration group founded a leading posture In this particular ceesdekker.net field of exploration. Dekker and his analysis team uncovered new physics of nanotubes in addition to explored the feasibility of molecular electronics. In 1998, they were being the primary to build a transistor determined by a single nanotube molecule.
2005, discovery from the system of DNA uncoiling by topoisomerase enzymes; discovery of lengthy-array conformational adjustments in Mre11/DNA maintenance complexes; and very first drive measurements on a DNA molecule in the nanopore
‘I'm driven by surprise and inquiries. On a cloth stage I obtain solutions in physics, but I expertise my deepest happiness with God. That religion also drives my science And exactly how I cope with folks.